What to Expect From Your First NAD+ Infusion Experience
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In recent years, the NAD+ infusion experience has gained serious traction in wellness communities, biohacking circles, and even clinical settings. At Mirako Spa, we’ve seen a growing number of clients curious about the NAD+ infusion experience, especially first-timers wondering what happens during a session. While the idea of intravenous vitamins and cellular rejuvenation may sound futuristic, the NAD+ infusion experience is rooted in real biochemistry and peer-reviewed science. If you’re considering your first NAD+ infusion, this guide breaks down what to expect, without the fluff, just facts that matter.
Understanding NAD+: The Science Behind the Hype
NAD+ (Nicotinamide Adenine Dinucleotide) is a coenzyme found in all living cells. It plays a vital role in mitochondrial function, energy production, and cellular repair. As we age, our NAD+ levels naturally decline — a process linked to fatigue, cognitive decline, and various metabolic disorders. Studies published in Nature and Cell Metabolism have shown that boosting NAD+ levels can improve insulin sensitivity, enhance mitochondrial performance, and even extend lifespan in animal models.
The NAD+ infusion experience provides a more direct way to replenish this essential molecule. NAD+ is involved in over 500 enzymatic reactions, many of which are central to cellular health. Its importance is so foundational that Harvard scientist Dr. David Sinclair has called NAD+ “one of the most important molecules for life.” While your body can synthesize NAD+ through precursors like niacin and tryptophan, direct infusion provides a more immediate and bioavailable route — hence the rise in NAD+ infusion experience therapies.
Why People Turn to NAD+ Infusion Therapy
Before diving into the actual NAD+ infusion experience, it helps to know why people choose this therapy in the first place. According to clinical reports and observational studies, patients seek NAD+ IV infusions for a variety of reasons:
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Fatigue and burnout
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Cognitive decline or brain fog
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Post-COVID recovery support
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Addiction recovery (used in some protocols)
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Athletic recovery and performance optimization
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General anti-aging and wellness goals
In a 2020 review published in Frontiers in Aging Neuroscience, researchers found promising correlations between NAD+ supplementation and improved neurocognitive function. While more human clinical trials are still underway, the early evidence supports the idea that the NAD+ infusion experience can help restore cellular balance.
What Happens Before the Infusion?
When you arrive for your NAD+ infusion experience, the process is more clinical than you might expect — but in a good way. No candles or spa music just yet. Here’s what typically happens before the IV drip begins:
1. Health Screening and Consent
A trained medical professional will review your medical history, allergies, current medications, and overall health status. You’ll be asked to sign a consent form acknowledging that NAD+ infusion experience therapy is still under ongoing scientific evaluation.
2. Vital Signs and Baseline Assessment
Your blood pressure, pulse, and oxygen levels will be taken. This helps determine your current physiological state and ensure you’re stable enough for the session. NAD+ can cause mild side effects if infused too quickly, so this baseline helps determine the safest infusion rate for your NAD+ infusion experience.
3. Discussion of Goals
You may be asked why you’re pursuing the NAD+ infusion experience. Whether it’s mental clarity, energy, or recovery, this information helps tailor your infusion plan and allows staff to set realistic expectations.
The NAD+ Infusion Experience: What It Feels Like
The infusion itself typically lasts 60 to 90 minutes, depending on dosage and your tolerance. Here’s a breakdown of what you might experience during that time:
1. Needle Insertion and Drip Setup
A nurse will insert an IV line, usually into your forearm or hand. The NAD+ solution is then diluted with sterile saline and administered slowly through the IV, marking the beginning of your NAD+ infusion experience.
2. The “Warm Flush” Sensation
Many first-time users report a warm, tingling sensation — especially in the chest or abdomen. This is completely normal and usually passes in the first 10 to 15 minutes of the NAD+ infusion experience. It’s often described as a “slow burn” but is generally tolerable.
Tip: If the infusion feels too intense during your NAD+ infusion experience, tell your nurse. Slowing the drip rate can significantly reduce discomfort.
3. Mental Clarity or Drowsiness
Depending on your current NAD+ levels and sensitivity, you may feel either a subtle lift in focus or a deep sense of relaxation. Some people even get sleepy during their first NAD+ infusion experience — this is part of the cellular recalibration process, not a side effect.
4. Hydration and Bathroom Breaks
Since NAD+ is metabolized quickly, it’s important to stay hydrated. You might feel the need to use the bathroom mid-session during your NAD+ infusion experience, and that’s normal. Just let your provider know so they can safely pause and resume the drip.
After the Session: What You Might Notice
Once your NAD+ infusion experience is complete, you may feel any of the following within the first few hours or days:
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Increased mental clarity or alertness
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More physical energy
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Better sleep quality that night
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Reduced cravings (in some addiction recovery contexts)
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Slight soreness or fatigue (rare and usually short-lived)
Clinical feedback suggests that many benefits of the NAD+ infusion experience are cumulative. That means the real payoff often comes after several sessions. A 2019 report from Harvard Health Publishing emphasized that NAD+ treatment may require ongoing administration for sustained results, especially in people over 40.
Is NAD+ Infusion Safe?
For most healthy individuals, the NAD+ infusion experience is safe. When administered by trained professionals in controlled environments, NAD+ IV therapy has a good safety profile. Mild side effects can include:
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Headache
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Nausea (if infused too quickly)
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Flushing
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Light chest pressure
All of these effects are generally transient and can be managed by adjusting the drip rate during your NAD+ infusion experience. As with any IV therapy, the risk of infection or vein irritation is present but rare when proper hygiene is followed.
People with chronic conditions like cardiovascular disease, liver disorders, or autoimmune diseases should consult a physician before starting the NAD+ infusion experience. Pregnant or breastfeeding individuals are typically advised to wait.
How Many Sessions Do You Need?
There’s no one-size-fits-all answer when it comes to the NAD+ infusion experience. Protocols vary depending on your goals. Here are some common patterns:
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General wellness: 1–2 sessions per month
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Fatigue or burnout: Once a week for 4–6 weeks
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Addiction recovery: Daily sessions for 7–14 days under medical supervision
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Anti-aging or performance: Monthly infusions or as part of a broader longevity plan
Think of the NAD+ infusion experience as a foundation, not a cure-all. Supporting your infusion with healthy habits (nutrition, sleep, stress reduction) will amplify its benefits.
Final Thoughts: Is NAD+ Worth Trying?
The NAD+ infusion experience is more than just a wellness trend. Backed by decades of biochemical research and emerging clinical data, it holds promise for those looking to optimize their energy, cognition, and overall vitality. That said, results vary. What works for one person might feel underwhelming for another, and that’s okay. Like many things in wellness, the key is consistency and personal fit.
At Mirako Spa, we believe education is just as important as any service we offer. Whether you’re stepping into your first NAD+ infusion experience or still weighing the pros and cons, being informed helps you make better decisions for your body and mind.
Read more:
The Science of NAD+ Mitochondrial Health: Unlocking Energy, Radiance, and Longevity
Why Fruit Stem Cell Facials Are the Future of Glowing Skin in Garden Grove
